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POSTDOCTORAL SCHOLARRequisition # 3417Position BasicsAdvertising Ends on:Monday, March 1st, 2021Advertising Started on:Wednesday, November 11th, 2020College:College of PharmacyDepartment:Pharmaceutical Sciences and Experimental TherapeuticsSalarySalary:$52,704.00 to CommensuratePosition DetailsFull/Part Time Status:Full TimePercent Time:100%Position Description:Postdoctoral Research Scholar needed for Structure-Based Drug DiscoveryThe Spies research group, in the College of Pharmacy's Division of Medicinal and Natural Products Chemistry (MNPC) and the Carver College of Medicine's Department of Biochemistry, seeks highly motivated postdoctoral scholar candidates for structure-based drug discovery.About our ResearchOur research focuses on allosteric drug discovery, directed against a wide range of enzymatic drug targets, with disease foci including anti-infectives, cancer and Parkinson's disease. Our work in structure based drug discovery has often focused on novel approaches in combining molecular dynamics (MD) simulations with cheminformatics and X-ray crystallography, in order to gain better insight into protein-ligand interactions, and provide new platforms for drug-discovery. Our lab is currently supported by two NIH R01 awards focusing on allosteric drug discovery (GM138471, GM097373).To learn more about what we do, examples of work are: Dean et al., ACS Central Science (2015)PMID: 26539562, Vance et al., Angewandte Chemi (2017) PMID: 28940929, Hengel et al., eLife (2016) PMID: 27434671, Witken et al., ChemMedChem (2020)PMID: 31876113.The research group is housed in the College of Pharmacy Building, a state-of-the-art research and teaching facility, recently completed at a cost of $128 million, providing an exciting and unparalleled work environment for conducting cutting-edge drug discovery research. This position will provide numerous opportunities to hone analytical and scientific writing skills, by working closely with the Principal Investigator on grants and manuscripts in the field. Additionally, the postdoctoral scholar's structural expertise will be strongly enhanced in the areas of computational chemistry and drug discovery, and a variety of complementary techniques.Applicants should have an excellent background in some combination of the following areas: structural biology (preferably X-ray crystallography), protein biochemistry, enzymology, biophysical chemistry, drug discovery and/or cheminformatics.Education Requirement:PhD in Chemistry, Pharmaceutical Sciences, Biochemistry or a related field (PhD degree completed by date of hire)Required Qualifications:Excellence in their field by evidence of completed research projects and publications.Strong background in some combination of the following areas: structural biology (preferably X-ray crystallography), protein biochemistry, enzymology, biophysical chemistry, drug discovery and/or cheminformatics.Desirable Qualifications:Protein biochemistry and X-ray crystallography or NMROnline Application Required DocumentsCurriculum VitaName and Contact Information of ReferencesLetters of InterestNumber of References: 2To start the Online Application process for this position, click the "Apply for This Position" button located below the Contact Information.Contact InformationContact:Dr. Ashley Spiesm-ashley-spies@uiowa.eduDepartment URL: University of Iowa is an equal opportunity/affirmative action employer. All qualified applicants are encouraged to apply and will receive consideration for employment free from discrimination on the basis of race, creed, color, national origin, age, sex, pregnancy, sexual orientation, gender identity, genetic information, religion, associational preference, status as a qualified individual with a disability, or status as a protected veteran. The University also affirms its commitment to providing equal opportunities and equal access to University facilities. Women and Minorities